一、個人簡介

   李紅燕，藥物化學專業(yè)博士研究生，2020年05月加入青島科技大學海洋科學與生物工程學院，主要從事海洋生物資源化學與生物活性、功效因子穩(wěn)態(tài)化及納米遞送等相關研究。主持省部級科研項目多項，在《Carbohydrate Polymers》、《International Journal of Biological Macromolecules》等國際學術期刊發(fā)表SCI論文40余篇，申請發(fā)明專利多件，擔任《Carbohydrate Polymers》、《International Journal of Biological Macromolecules》、《Glycoconjugate Journal》等國際學術期刊審稿人。

二、研究方向

1. 海洋生物資源活性成分化學結構及功能評價

2. 海洋生物功效因子穩(wěn)態(tài)化及納米遞送

三、教育及工作經(jīng)歷

2020.5-至今     青島科技大學

2017.6-2020.4   中國海洋大學 食品科學與工程學院 博士后

2011.7-2017.5   河北大學 化學與材料科學學院

2006.9-2011.6   中國海洋大學 藥物化學 博士

2004.7-2006.8   山東淄博新達制藥有限公司 質量部工程師

2000.9-2004.6   湖北中醫(yī)藥大學 藥學 學士

四、個人榮譽與獲獎

1. 第八屆全國大學生生命科學競賽（創(chuàng)新組CULSC2023CXCY1846），國家三等獎，指導老師

2. 第八屆全國大學生生命科學競賽（創(chuàng)新組CULSC2023SD-2-078），山東省二等獎，指導老師

3. 2023年度大學生創(chuàng)新創(chuàng)業(yè)項目（S202310426309），省級立項，指導老師

4. 2022年度大學生創(chuàng)新創(chuàng)業(yè)項目，校級立項，指導老師

5. 2020年度山東省食品科學技術學會科學技術獎叁等獎，6/10

五、承擔的主要科研項目

1. 國家自然科學基金項目，32072348，嗜鹽菌代謝影響傳統(tǒng)發(fā)酵蝦醬特征風味形成的分子機制，參與

2. 青島科技大學高層次人才啟動經(jīng)費，主持

3. 食品質量與安全北京實驗室（FQS-202108），殼聚糖衍生物對扇貝中PSTs毒素的消減機制研究，主持

4. 青島寶創(chuàng)生物科技有限公司，海洋真菌胞外多糖研發(fā)技術，主持

5. 中國博士后科學基金項目，2018M642706，海參皂苷靶向長效納米脂質體的制備及抗乳腺癌活性研究，主持

6. 山東省博士后創(chuàng)新項目，肝靶向苦菜多糖的制備、結構及抗肝癌作用研究，主持

7. 河北省自然科學基金項目，B2015201069，板栗多糖資源開發(fā)的基礎研究，主持

8. 河北省教育廳項目，QN2014131，以拓撲異構酶I為靶點的板栗多糖活性片段的篩選與結構表征，主持

9. 國家自然科學基金項目，41076086，礁膜抗凝血活性鼠李聚糖硫酸酯的可控降解與構效關系研究，參與

六、教學情況

1. 主講本科生課程《海洋資源學》、《海洋藥物》

2. 主講研究生課程《海洋資源的開發(fā)與利用》、《海洋生物資源化學》、《生物活性物質波譜解析》

七、論文與專利

       1. Che Hongxia, Wang Xiyu, He Shusen, Dong Xiufang, Lv Liangtao, Xie Wancui*, Li Hongyan*. Orally administered selenium-containing α-D-1,6-glucan and α-D-1,6-glucan relief early cognitive deficit in APP/PS1 mice. International Journal of Biological Macromolecules, 2024, 257, 128539.

        2. Li Hongyan*, Cui Huanhuan, Cong Peixu, Xu Jie, Xie Wancui, Wang Yuming, Xue Changhu. Echinoside A from Pearsonothuria graeffei exert the cytotoxicity to MDA-MB-231 cells via mitochondrial and modulation of PI3K/Akt/mTOR pathway. Journal of Ocean University of China, 2023, 22, 205-212.

        3. Li Hongyan*, Wang Yifan, Chen Yan, Wang Shuxin Zhao Yifan, Sun Jinyuan*. Arabinogalactan from Ixeris chinensis (Thunb.) Nakai as a stabilizer to decorate SeNPs and enhance their anti-hepatocellular carcinoma activity via the mitochondrial pathway. Journal of Carbohydrate Chemistry, 2022, 41, 329-345.

        4. Li Hongyan*, Cao Wanxiu, Xie Jingwen, Hongxia Che, Dong Xiufang, Song Lin, Xie Wancui*. The α-D-1,6-glucan from Castanea mollissima Blume alleviates dextran sulfate sodium-induced colitis in vivo. Carbohydrate Polymers, 2022, 289, 119410.

        5. Li Hongyan*, Che Hongxia, Xie Jingwen, Dong Xiufang, Song Lin, Xie Wancui, Sun Jinyuan*. Supplementary selenium in the form of selenylation α-D-1,6-glucan ameliorates dextran sulfate sodium induced colitis in vivo. International Journal of Biological Macromolecules, 2022, 195, 67-74.

        6. Li Hongyan, Xie Wancui, Sun Haihong, Cao Kewei, Yang, Xihong*, Effect of structural characterization of the fungal polysaccharides on their immunomodulatory activity. International Journal of Biological Macromolecules, 2020, 164: 3603-3610.

        7. Li Hongyan*; Xie Wancui; Qiao Xing; Cui Huanhuan; Yang Xihong; Xue Changhu, Structural characterization of arabinogalactan extracted from Ixeris chinensis (Thunb.) Nakai and its immunomodulatory effect on RAW264.7 macrophages. International Journal of Biological Macromolecules, 2020, 143: 977-983.

        8. Li Hongyan*, Liu Dandan, Li Shenghui, Xue Changhu*, Synthesis and cytotoxicity of selenium nanoparticles stabilized by α-D-glucan from Castanea mollissima Blume. International Journal of Biological Macromolecules, 2019, 129, 818-826.

        9. Cui Huanhuan, Li Hongyan*, Wang Yingxing, Li Shenghui, Xue Changhu*, Structural characterization and biological activity of galactoglucan from Castanea mollissima Blume. Journal of Carbohydrate Chemistry, 2019, 38, 398-411.

        10. Li Hongyan*, Cao Kewei, Cong Peixu, Liu Yanjun, Cui Huanhuan, Xue Changhu*, Structure characterization and antitumor activity of the extracellular polysaccharide from the marine fungus Hansfordia sinuosae. Carbohydrate Polymers, 2018, 190, 87-94.

        11. Li Hongyan, Wang Yingxing, Wang Chao, Zhang Shaohan, Li Shenghui*, Zhou Guoqiang, Wang Shuxiang, Zhang Jinchao*, Extraction, selenylation modification and antitumor activity of the glucan from Castanea mollissima Blume. Glycoconjugate Journal, 2017, 34, 207-217.

        12. Li Hongyan*, Yu He, Zhu Huajie*. Structure studies of the extracellular polysaccharide from Trichoderma sp. KK19L1 and its antitumor effect via cell cycle arrest and apoptosis, Applied Biochemistry and Biotechnology, 2017, 182:128-141.

        13. Li Hongyan*, Liu Xin, Xu Yan, Wang Xiaoke, Zhu Huajie*, Structure and antitumor activity of the extracellular polysaccharides from Aspergillus aculeatus via apoptosis and cell cycle arrest. Glycoconjugate Journal, 2016, 33, 975-984.

        14. Li Hongyan*, Gao Tong, Wang Jingchen, Tian Shasha, Yuan Xin，Zhu Huajie*, Structure identification and antitumor activity of the extracellular polysaccharide from Aspergillus terreus. Process Biochemistry, 2016, 51, 1714-1720.

        15. Li Hongyan, Mao Wenjun*, Hou Yujiao, Gao Yan, Qi Xiaohui, Zhao Chunqi, Chen Yin, Chen Yanli, Li Na, Wang Chunyan, Preparation, structure and anticoagulant activity of a low molecular weight fraction produced by mild acid hydrolysis of the sulfated rhamnan from Monostroma latissimum. Bioresource Technology, 2012, 114, 414-418.

        16. Li Hongyan, Mao Wenjun*, Chen Yin, Ren Sumei, Qi Xiaohui, Chen Yanli, Zhao Chunqi, Li Na, Wang Chunyan, Lin Cong, Yan Mengxia, Shan Jimiao, Sequence analysis of the sulfated rhamno-oligosaccharides derived from a sulfated rhamnan. Carbohydrate Polymers, 2012, 90:1299-1304.

        17. Li Hongyan, Mao Wenjun*, Zhang Xiuli, Qi Xiaohui, Chen Yin, Chen Yanli, Xu Jian, Zhao Chunqi, Hou Yujiao, Yang Yupin, Li Na, Wang Chunyan, Structural characterization of an anticoagulant -active sulfated polysaccharide isolated from green alga Monostroma latissimum. Carbohydrate Polymers, 2011, 85, 394-400.

        18. Mao Wenjun*, Li Hongyan, Li Yi, Zhang Huijuan, Qi Xiaohui, Sun Haihong, Chen Yin, Guo Shoudong, Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta), International Journal of Biological Macromolecules, 2009, 44:70-74.

專利：

1. 李紅燕，解萬翠，楊錫洪，車紅霞，董秀芳，宋琳。一種丹皮線性α-D-1,4-葡聚糖及其制備方法和應用。2022.6.7 ZL202110883581.8

2. 李紅燕，解萬翠，楊錫洪，車紅霞，董秀芳，宋琳。一種包載海參皂苷的自組裝納米體系及其制備方法和應用。2022.6.3 ZL202011622525.0

3. 李紅燕，解萬翠，楊錫洪，宋琳，車紅霞，董秀芳。一種天麻大分子線性直鏈葡聚糖及其制備方法和應用。2022.5.31 ZL202011469544.4

4. 李紅燕，王應杏，張金超，王書香，李勝輝，周國強，劉丹丹。板栗種仁α-1,6-葡聚糖及其制備方法以及在抗腫瘤藥物中的應用，2017.8.25，中國，ZL201510333089.8

5. 薛長湖，李紅燕，崔歡歡，柯梟，徐杰，王玉明，李兆杰。一種可供注射給藥的海參皂苷納米脂質體，其制備方法及在抗腫瘤藥物中的應用，2021.7.23，中國，ZL201910203903.2

6. 李紅燕，解萬翠，楊錫洪，董秀芳，宋琳，車紅霞。一種可供注射的海參皂苷介孔二氧化硅納米復合物及其制備方法和應用。202011625912.X

7. 李紅燕，解萬翠，楊錫洪，董秀芳，車紅霞，宋琳。一種蝦青素-殼聚糖自組裝納米復合物及其制備方法和應用。202110955254.9。

8. 李紅燕，解萬翠，楊錫洪，車紅霞，董秀芳，宋琳。一種透明質酸-蝦青素納米復合物及其制備方法與應用。202111562607.5。

9. 李紅燕，解萬翠，楊錫洪，董秀芳，車紅霞，宋琳。A hyaluronic acid-astaxanthin self-assembled nano system and the preparation method and its application. Patent number: 2021106295. 國際專利

10. 李紅燕，解萬翠，楊錫洪，車紅霞，董秀芳，宋琳。Extraction and preparation of the acidic polysaccharide extracted from Kaempfeia galangal L and its application in antibacterial preservation. Patent number: 2021106002. 國際專利